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A fast and highly sensitive blood culture PCR method for clinical detection of Salmonella enterica serovar Typhi.

Abstract:

BACKGROUND: Salmonella Typhi causes an estimated 21 million new cases of typhoid fever and 216,000 deaths every year. Blood culture is currently the gold standard for diagnosis of typhoid fever, but it is time-consuming and takes several days for isolation and identification of causative organisms. It is then too late to initiate proper antibiotic therapy. Serological tests have very low sensitivity and specificity, and no practical value in endemic areas. As early diagnosis of the disease a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1476-0711-9-14

Authors


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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
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Funding agency for:
Pollard, A
National Institute for Health Research Biomedical Research Centre Programme More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Annals of Clinical Microbiology and Antimicrobials Journal website
Volume:
9
Issue:
1
Article number:
14
Publication date:
2010-01-01
DOI:
EISSN:
1476-0711
ISSN:
1476-0711
Source identifiers:
119375
Language:
English
Keywords:
UUID:
uuid:d103eb16-c60d-485a-bd3e-808db1a19725
Local pid:
pubs:119375
Deposit date:
2012-12-19

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