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Gestational vitamin D supplementation leads to reduced perinatal RXRA DNA methylation: results from the MAVIDOS trial

Abstract:

We have previously demonstrated inverse associations between maternal 25(OH)-vitamin D status and perinatal DNA methylation at the retinoid-X-receptor-alpha (RXRA) locus and between RXRA methylation and offspring bone mass. In this study, we used an existing randomized trial to test the hypothesis that maternal gestational vitamin D supplementation would lead to reduced perinatal RXRA locus DNA methylation. The Maternal Vitamin D Osteoporosis Study (MAVIDOS) was a multicenter, double-blind, r...

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Publication status:
Published
Peer review status:
Peer Reviewed
Version:
Publisher's Version

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Publisher copy:
10.1002/jbmr.3603

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Role:
Author
ORCID:
0000-0002-5147-0550
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Publisher:
Wiley Publisher's website
Journal:
Journal of Bone and Mineral Research Journal website
Volume:
34
Issue:
2
Pages:
231-240
Publication date:
2018-10-15
Acceptance date:
2018-10-16
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
Pubs id:
pubs:929781
URN:
uri:d1037c52-03ee-4cc8-a576-7913d1be9033
UUID:
uuid:d1037c52-03ee-4cc8-a576-7913d1be9033
Local pid:
pubs:929781
Language:
English
Keywords:

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