- Abstract:
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We have previously demonstrated inverse associations between maternal 25(OH)-vitamin D status and perinatal DNA methylation at the retinoid-X-receptor-alpha (RXRA) locus and between RXRA methylation and offspring bone mass. In this study, we used an existing randomized trial to test the hypothesis that maternal gestational vitamin D supplementation would lead to reduced perinatal RXRA locus DNA methylation. The Maternal Vitamin D Osteoporosis Study (MAVIDOS) was a multicenter, double-blind, r...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer Reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 406.4KB)
-
- Publisher copy:
- 10.1002/jbmr.3603
-
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- Publisher:
- Wiley Publisher's website
- Journal:
- Journal of Bone and Mineral Research Journal website
- Volume:
- 34
- Issue:
- 2
- Pages:
- 231-240
- Publication date:
- 2018-10-15
- Acceptance date:
- 2018-10-16
- DOI:
- EISSN:
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1523-4681
- ISSN:
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0884-0431
- Pubs id:
-
pubs:929781
- URN:
-
uri:d1037c52-03ee-4cc8-a576-7913d1be9033
- UUID:
-
uuid:d1037c52-03ee-4cc8-a576-7913d1be9033
- Local pid:
- pubs:929781
- Language:
- English
- Keywords:
- Copyright holder:
- Curtis et al.
- Copyright date:
- 2018
- Notes:
- © The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Journal article
Gestational vitamin D supplementation leads to reduced perinatal RXRA DNA methylation: results from the MAVIDOS trial
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