- Abstract:
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The phosphatidylinositol 3-kinase (PI3K) pathway is activated in chronic obstructive pulmonary disease (COPD), but the regulatory mechanisms for this pathway are yet to be elucidated. The aim of this study was to determine the expression and role of phosphatase and tensin homolog deleted from chromosome 10 (PTEN), a negative regulator of the PI3K pathway, in COPD. PTEN protein expression was measured in the peripheral lung of COPD patients compared with smoking and nonsmoking controls. The di...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 1.6MB)
-
- Publisher copy:
- 10.1152/ajplung.00382.2016
-
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- Publisher:
- American Physiological Society Publisher's website
- Journal:
- American Journal of Physiology. Lung cellular and Molecular Physiology Journal website
- Volume:
- 313
- Issue:
- 2
- Pages:
- L230-L239
- Publication date:
- 2017-08-01
- Acceptance date:
- 2017-05-05
- DOI:
- EISSN:
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1522-1504
- ISSN:
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1040-0605
- Pubs id:
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pubs:826139
- URN:
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uri:d1026bc6-57c6-4798-be57-67ccf43552b0
- UUID:
-
uuid:d1026bc6-57c6-4798-be57-67ccf43552b0
- Local pid:
- pubs:826139
- Copyright holder:
- American Physiological Society
- Copyright date:
- 2017
- Notes:
- © 2017 the American Physiological Society. Licensed under Creative Commons Attribution CC-BY 4.0.
Journal article
Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD
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