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Journal article

Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD

Abstract:

The phosphatidylinositol 3-kinase (PI3K) pathway is activated in chronic obstructive pulmonary disease (COPD), but the regulatory mechanisms for this pathway are yet to be elucidated. The aim of this study was to determine the expression and role of phosphatase and tensin homolog deleted from chromosome 10 (PTEN), a negative regulator of the PI3K pathway, in COPD. PTEN protein expression was measured in the peripheral lung of COPD patients compared with smoking and nonsmoking controls. The di...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1152/ajplung.00382.2016

Authors


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Role:
Author
ORCID:
0000-0003-3895-5518
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Role:
Author
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Role:
Author
ORCID:
0000-0002-0753-5425
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Publisher:
American Physiological Society Publisher's website
Journal:
American Journal of Physiology. Lung cellular and Molecular Physiology Journal website
Volume:
313
Issue:
2
Pages:
L230-L239
Publication date:
2017-08-01
Acceptance date:
2017-05-05
DOI:
EISSN:
1522-1504
ISSN:
1040-0605
Pubs id:
pubs:826139
URN:
uri:d1026bc6-57c6-4798-be57-67ccf43552b0
UUID:
uuid:d1026bc6-57c6-4798-be57-67ccf43552b0
Local pid:
pubs:826139

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