Journal article icon

Journal article

The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells.

Abstract:

Although much is known about globin gene activation in erythroid cells, relatively little is known about how these genes are silenced in nonerythroid tissues. Here we show that the human alpha- and beta-globin genes are silenced by fundamentally different mechanisms. The alpha-genes, which are surrounded by widely expressed genes in a gene dense region of the genome, are silenced very early in development via recruitment of the Polycomb (PcG) complex. By contrast, the beta-globin genes, which...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
Blood
Volume:
112
Issue:
9
Pages:
3889-3899
Publication date:
2008-11-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:d0fddeab-255b-4756-b464-bc046cb241ab
Source identifiers:
124727
Local pid:
pubs:124727

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP