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TP53 and KRAS2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence: A prospective study

Abstract:

In cancer patients, plasma often contains mutant DNA released by cancer cells. We have assessed the significance of plasma DNA mutations for subsequent cancer development in healthy subjects in a large longitudinal prospective study. The European Prospective Investigation into Cancer and Nutrition study was analyzed with a nested case-control design. Cases were nonsmokers or ex-smokers for >10 years and newly diagnosed with lung, bladder, or upper aerodigestive tract cancers or leukemia ac...

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Journal:
Cancer Research
Volume:
66
Issue:
13
Pages:
6871-6876
Publication date:
2006-07-01
DOI:
ISSN:
0008-5472
URN:
uuid:d0fbee73-8087-4d92-9658-77345799bb74
Source identifiers:
74877
Local pid:
pubs:74877
Language:
English

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