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MmpL3 is a lipid transporter that binds trehalose monomycolate and phosphatidylethanolamine

Abstract:

The cell envelope of Mycobacterium tuberculosis is notable for the abundance of mycolic acids (MAs), essential to mycobacterial viability, and of other species-specific lipids. The mycobacterial cell envelope is extremely hydrophobic, which contributes to virulence and antibiotic resistance. However, exactly how fatty acids and lipidic elements are transported across the cell envelope for cell-wall biosynthesis is unclear. Mycobacterial membrane protein Large 3...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1901346116

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
ORCID:
0000-0003-4346-182X
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Oxford college:
Exeter College
Role:
Author
ORCID:
0000-0001-7829-5505
Publisher:
National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
116
Issue:
23
Pages:
11241-11246
Publication date:
2019-05-21
Acceptance date:
2019-05-03
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pmid:
31113875
Language:
English
Keywords:
Pubs id:
pubs:1003112
UUID:
uuid:d0f926b0-5026-40bb-972e-288295c04e12
Local pid:
pubs:1003112
Source identifiers:
1003112
Deposit date:
2019-07-02

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