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Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.

Abstract:

Concerns over cardiac side effects are the largest single cause of compound attrition during pharmaceutical drug development. For a number of years, biophysically detailed mathematical models of cardiac electrical activity have been used to explore how a compound, interfering with specific ion-channel function, may explain effects at the cell-, tissue- and organ-scales. With the advent of high-throughput screening of multiple ion channels in the wet-lab, and improvements in computational mode...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Computer Science
Davies, MR More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
British journal of pharmacology
Volume:
167
Issue:
5
Pages:
932-945
Publication date:
2012-11-05
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:d0f69a6a-5765-4ade-a946-1695873608df
Source identifiers:
329098
Local pid:
pubs:329098

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