- Abstract:
-
Concerns over cardiac side effects are the largest single cause of compound attrition during pharmaceutical drug development. For a number of years, biophysically detailed mathematical models of cardiac electrical activity have been used to explore how a compound, interfering with specific ion-channel function, may explain effects at the cell-, tissue- and organ-scales. With the advent of high-throughput screening of multiple ion channels in the wet-lab, and improvements in computational mode...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1111/j.1476-5381.2012.02020.x
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- Journal:
- British journal of pharmacology
- Volume:
- 167
- Issue:
- 5
- Pages:
- 932-945
- Publication date:
- 2012-11-05
- DOI:
- EISSN:
-
1476-5381
- ISSN:
-
0007-1188
- URN:
-
uuid:d0f69a6a-5765-4ade-a946-1695873608df
- Source identifiers:
-
329098
- Local pid:
- pubs:329098
- Copyright date:
- 2012
Journal article
Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.
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