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Structure of the hexameric fungal plasma membrane proton pump in its autoinhibited state

Abstract:

The fungal plasma membrane H+-ATPase Pma1 is a vital enzyme, generating a proton-motive force that drives the import of essential nutrients. Autoinhibited Pma1 hexamers in the plasma membrane of starving fungi are activated by glucose signaling and subsequent phosphorylation of the autoinhibitory domain. As related P-type adenosine triphosphatases (ATPases) are not known to oligomerize, the physiological relevance of Pma1 hexamers remained unknown. We have determined the structure of hexameri...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/sciadv.abj5255

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Role:
Author
ORCID:
0000-0003-1670-8081
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Role:
Author
ORCID:
0000-0001-6341-9368
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
ORCID:
0000-0003-1820-7993
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Role:
Author
ORCID:
0000-0003-0904-1119
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John Fell Fund More from this funder
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Advances Journal website
Volume:
7
Issue:
46
Article number:
eabj5255
Publication date:
2021-11-10
Acceptance date:
2021-09-22
DOI:
EISSN:
2375-2548
Language:
English
Keywords:
Pubs id:
1210348
Local pid:
pubs:1210348
Deposit date:
2021-11-18

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