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NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells.

Abstract:

Modification in the function of dendritic cells (DC), such as that achieved by microbial stimuli or T cell help, plays a critical role in determining the quality and size of adaptive responses to Ag. NKT cells bearing an invariant TCR (iNKT cells) restricted by nonpolymorphic CD1d molecules may constitute a readily available source of help for DC. We therefore examined T cell responses to i.v. injection of soluble Ag in the presence or the absence of iNKT cell stimulation with the CD1d-bindin...

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Publication status:
Published

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Journal:
Journal of Immunology More from this journal
Volume:
171
Issue:
10
Pages:
5140-5147
Publication date:
2003-11-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767

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