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A flexible and accurate genotype imputation method for the next generation of genome-wide association studies

Abstract:

Genotype imputation methods are now being widely used in the analysis of genome-wide association studies. Most imputation analyses to date have used the HapMap as a reference dataset, but new reference panels (such as controls genotyped on multiple SNP chips and densely typed samples from the 1,000 Genomes Project) will soon allow a broader range of SNPs to be imputed with higher accuracy, thereby increasing power. We describe a genotype imputation method (IMPUTE version 2) that is designed t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Role:
Author
More from this funder
Name:
National Science Foundation
Funding agency for:
Howie, B
More from this funder
Name:
"Wellcome Trust", "Wolfson Foundation", "Wolfson-Royal Society Merit Award"
Funding agency for:
Donnelly, P
More from this funder
Name:
Wellcome Trust
Grant:
076113
Publisher:
Public Library of Science
Journal:
PLoS Genetics More from this journal
Volume:
5
Issue:
6
Article number:
e1000529
Publication date:
2009-06-01
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Language:
English
Subjects:
UUID:
uuid:d0f1793e-c57e-43b8-867c-eb3087255c8c
Local pid:
ora:6000
Deposit date:
2012-01-10

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