Journal article icon

Journal article

The role of the Xist 5' m6A region and RBM15 in X chromosome inactivation

Abstract:
Background: X chromosome inactivation in mammals is regulated by the non-coding (nc) RNA, Xist, which represses the chromosome from which it is transcribed. High levels of the N6-methyladenosine (m6A) RNA modification occur within Xist exon I, close to the 5’ end of the transcript, and also further 3’, in Xist exon VII. The m6A modification is catalysed by the METTL3/14 complex that is directed to specific targets, including Xist, by the RNA binding protein RBM15/15B. m6A mo... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More by this author
Role:
Author
ORCID:
0000-0001-9570-944X
More by this author
Role:
Author
ORCID:
0000-0002-5698-426X
More by this author
Role:
Author
ORCID:
0000-0003-3915-7892
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
ORCID:
0000-0003-2640-9560
More by this author
Institution:
University of Oxford
Division:
MSD
Sub department:
Biochemistry
Role:
Author
ORCID:
0000-0001-7740-4386
More from this funder
Name:
Wellcome Trust
Grant:
215513/Z/19/Z
Publisher:
F1000Research
Journal:
Wellcome Open Research More from this journal
Volume:
5
Article number:
31
Place of publication:
England
Publication date:
2020-02-17
Acceptance date:
2020-03-18
DOI:
EISSN:
2398-502X
Pmid:
32258426
Language:
English
Keywords:
Pubs id:
1087954
Local pid:
pubs:1087954
Deposit date:
2021-05-20

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP