Utilisation of triacylglycerol and non-esterified fatty acid by the working rat heart: myocardial lipid substrate preference.

Journal article

Utilisation and subsequent metabolic fate (oxidation; tissue lipid deposition) of non-esterified fatty acid (NEFA), very-low-density lipoprotein-triacylglycerol (VLDL-TAG), and chylomicron-triacylglycerol (CM-TAG) alone or in combination by isolated working rat heart were examined. Cardiac mechanical function was maintained regardless of lipid substrate used. NEFA and CM-TAG were assimilated to a greater extent than VLDL-TAG; CM-TAG utilisation (76+/-10 nmol fatty acid/min per g wet wt.; n=8)...

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Authors: Hauton, D; Bennett, M; Evans, R

• Journal: Biochimica et biophysica acta
• Volume: 1533
• Issue: 2
• Pages: 99-109
• Publication date: 2001-09-01
• DOI: 10.1016/s1388-1981(01)00146-9
• ISSN: 0006-3002
• Language: English
• Keywords: Rats, Wistar; Heart; Perfusion; Carbon Radioisotopes; Myocardium; Animals; Tritium; Energy Metabolism; Male; Fatty Acids, Nonesterified; Lipoproteins, VLDL; Rats; Triolein; Chylomicrons; Triglycerides; Lipoprotein Lipase