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Application of hyperpolarized magnetic resonance in the study of cardiac metabolism

Abstract:

The application of magnetic resonance (MR) for metabolic imaging and spectroscopy has been limited by the intrinsically low sensitivity and natural abundance of 13C. Recently a method has been developed in which solid-state, dynamically polarized MR-active nuclei can be dissolved to obtain a solution polarized in excess of 20%. When used in concert with MR spectroscopy, this method of hyperpolarization provides the MR signal necessary to detect low-abundance molecules, enabling visualization ...

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Publication status:
Published

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Publisher copy:
10.1007/s00723-008-0115-7

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
APPLIED MAGNETIC RESONANCE More from this journal
Volume:
34
Issue:
3-4
Pages:
523-531
Publication date:
2008-08-01
DOI:
EISSN:
1613-7507
ISSN:
0937-9347
Language:
English
Pubs id:
pubs:106855
UUID:
uuid:d0e8d9cf-b81d-4df4-8230-6bd6e2957c3d
Local pid:
pubs:106855
Source identifiers:
106855
Deposit date:
2012-12-19

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