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Journal article

Activating calcium-sensing receptor mutation in the mouse is associated with cataracts and ectopic calcification.

Abstract:

The extracellular calcium-sensing receptor (CaSR) plays a pivotal role in the regulation of extracellular calcium such that abnormalities, which result in a loss or gain of function, lead to hypercalcemia or hypocalcemia, respectively, in patients. Mice carrying CaSR knockout alleles develop hypercalcemia that mimics the disorders observed in humans. To date, there is no mouse model for an activating CaSR mutation. Here, we describe such a mouse model, named Nuf, originally identified for hav...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0405516101

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
101
Issue:
37
Pages:
13566-13571
Publication date:
2004-09-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:8434
UUID:
uuid:d0e1495e-d876-441a-ba74-ea75cd28a791
Local pid:
pubs:8434
Source identifiers:
8434
Deposit date:
2013-09-17

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