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Similar ligand densities required for restimulation and effector function of cytotoxic T cells.

Abstract:

This study compared ligand densities on antigen-presenting cells (APCs) needed for in vitro restimulation of in vivo primed T cells and for in vitro assessed T cell effector function. Spleen cells of lymphocytic choriomeningitis virus (LCMV)-primed mice were restimulated in vitro with graded amounts of virus-derived peptides using macrophages or a cloned dendritic cell line as APCs. To test for effector function of these cytotoxic T cells, the same APCs pulsed with graded amounts of the pepti...

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Publication status:
Published

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Publisher copy:
10.1006/cimm.1997.1146

Authors


Oxenius, A More by this author
Bachmann, MF More by this author
Journal:
Cellular immunology
Volume:
179
Issue:
1
Pages:
16-21
Publication date:
1997-07-05
DOI:
EISSN:
1090-2163
ISSN:
0008-8749
URN:
uuid:d0e02aca-7172-4bf3-af5e-d32bec2c389c
Source identifiers:
469164
Local pid:
pubs:469164

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