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Campath-1G in vivo confers a low incidence of graft-versus-host disease associated with a high incidence of mixed chimaerism after bone marrow transplantation for severe aplastic anaemia using HLA-identical sibling donors.

Abstract:

We have evaluated the effect of in vivo Campath-1G on engraftment and GVHD in 23 patients with severe aplastic anaemia transplanted from HLA-identical sibling donors. In 14 patients Campath 1g was given pre-transplant for up to 9 days in an attempt to overcome graft rejection (group 1). In nine patients Campath-1G was given pre-transplant, but also continued post-transplant until day +5 to reduce GVHD (group 2). There were three patients with late graft failure in group I following initial ne...

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Publication status:
Published

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Authors


Hamblin, M More by this author
McCann, SR More by this author
Wickham, N More by this author
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Journal:
Bone marrow transplantation
Volume:
17
Issue:
5
Pages:
819-824
Publication date:
1996-05-05
EISSN:
1476-5365
ISSN:
0268-3369
URN:
uuid:d0dcd509-19bd-42e1-b76e-fcd82d4f32cf
Source identifiers:
1860
Local pid:
pubs:1860

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