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Macrophage metalloproteinases degrade high-density-lipoprotein-associated apolipoprotein A-I at both the N- and C-termini

Abstract:

Atheromatous plaques contain various cell types, including macrophages, endothelial cells and smooth-muscle cells. To investigate the possible interactions between secreted matrix metalloproteinases and high-density lipoprotein (HDL) components, we tested the above cell types by culturing them for 24 h. HDL3 (HDL subfractions with average sizes of between 8.44 nm for HDL3A and 7.62 nm for HDL3C) were then incubated in their cell-free conditioned media. Proteolytic degradation of apolipoprotei...

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Publisher copy:
10.1042/0264-6021:3620627

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Biochemical Journal
Volume:
362
Issue:
3
Pages:
627-634
Publication date:
2002-03-15
DOI:
ISSN:
0264-6021
URN:
uuid:d0dcb397-9e85-4dd2-b856-f2d5a6b260c8
Source identifiers:
231071
Local pid:
pubs:231071

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