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Journal article

Investigation of the mechanisms of anti-complement activity in Ixodes ricinus ticks.

Abstract:

The feeding success of a tick upon a host depends on its ability to suppress host anti-tick responses which include activation of the complement system. We investigated the mechanism of inhibition of the alternative pathway of complement by salivary gland extract (SGE) of the ixodid tick species, Ixodes ricinus. SGE treatment strongly inhibited C3a generation and factor B cleavage in serum when rabbit erythrocytes were used as complement activator, but not when cobra venom factor (CVF) was us...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
Journal:
Molecular immunology More from this journal
Volume:
42
Issue:
1
Pages:
31-38
Publication date:
2005-01-01
DOI:
EISSN:
1872-9142
ISSN:
0161-5890
Language:
English
Keywords:
Pubs id:
pubs:268809
UUID:
uuid:d0dc8f9a-ce04-45f3-b405-a2ff852227e5
Local pid:
pubs:268809
Source identifiers:
268809
Deposit date:
2013-11-16

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