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Density distribution of pharyngeal carriage of meningococcus in healthy young adults: new approaches to studying the epidemiology of colonization and vaccine indirect effects

Abstract:

Improved understanding of Neisseria meningitidis (Nm) carriage biology and better methods for detection and quantification would facilitate studies of potential impact of new vaccines on colonization and transmission in adolescents.We performed plate cultures on 107 oropharyngeal swabs stored frozen in STGG broth and previously positive for Nm. We compared quantitative (q)PCR detection of Nm in 601 STGG-swabs with culture. Using qPCR (n=87), a log-phase broth culture standard curve and semi-q...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1097/INF.0000000000001237

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Publisher:
Lippincott, Williams and Wilkins Publisher's website
Journal:
Pediatric Infectious Disease Journal Journal website
Volume:
35
Issue:
10
Pages:
1080–1085
Publication date:
2016-10-01
Acceptance date:
2016-05-25
DOI:
EISSN:
1532-0987
ISSN:
0891-3668
Source identifiers:
626953
Language:
English
Keywords:
Pubs id:
pubs:626953
UUID:
uuid:d0dade55-2903-4602-89e1-055393410e59
Local pid:
pubs:626953
Deposit date:
2016-06-26

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