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Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6) in breast cancer

Abstract:

Frizzled receptors mediate Wnt ligand signalling, which is crucially involved in regulating tissue development and differentiation, and is often deregulated in cancer. In this study, we found that the gene encoding the Wnt receptor frizzled 6 (FZD6) is frequently amplified in breast cancer, with an increased incidence in the triple-negative breast cancer (TNBC) subtype. Ablation of FZD6 expression in mammary cancer cell lines: (1) inhibited motility and invasion; (2) induced a more symmetrica...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/path.4841

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More from this funder
Name:
Italian Association of Cancer Research
Grant:
IG15196toVDL,
IG11652to MS
More from this funder
Name:
Breakthrough Breast Cancer
Publisher:
John Wiley & Sons Ltd
Journal:
Journal of Pathology More from this journal
Volume:
241
Issue:
3
Pages:
350-361
Publication date:
2016-12-29
Acceptance date:
2016-10-18
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
Language:
English
Keywords:
Pubs id:
pubs:700299
UUID:
uuid:d0d72522-2e47-449a-b4c6-844ed72bfc72
Local pid:
pubs:700299
Source identifiers:
700299
Deposit date:
2017-07-21

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