- Abstract:
-
AIMS/HYPOTHESIS: Rapamycin, part of the immunosuppressive regimen of the Edmonton protocol, has been shown to inhibit vascular endothelial growth factor (VEGF) production and VEGF-mediated survival signalling in tumour cell lines. This study investigates the survival-promoting activities of VEGF in human islets and the effects of rapamycin on islet viability. MATERIALS AND METHODS: Levels of VEGF and its receptors in isolated human islets and whole pancreas was determined by western blotting ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/s00125-007-0670-8
-
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- Journal:
- Diabetologia
- Volume:
- 50
- Issue:
- 7
- Pages:
- 1423-1432
- Publication date:
- 2007-07-05
- DOI:
- EISSN:
-
1432-0428
- ISSN:
-
0012-186X
- URN:
-
uuid:d0d50cb6-e4e1-4bcd-a4f6-01420cc3d877
- Source identifiers:
-
96049
- Local pid:
- pubs:96049
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
Vascular endothelial growth factor as a survival factor for human islets: effect of immunosuppressive drugs.
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