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Vascular endothelial growth factor as a survival factor for human islets: effect of immunosuppressive drugs.

Abstract:

AIMS/HYPOTHESIS: Rapamycin, part of the immunosuppressive regimen of the Edmonton protocol, has been shown to inhibit vascular endothelial growth factor (VEGF) production and VEGF-mediated survival signalling in tumour cell lines. This study investigates the survival-promoting activities of VEGF in human islets and the effects of rapamycin on islet viability. MATERIALS AND METHODS: Levels of VEGF and its receptors in isolated human islets and whole pancreas was determined by western blotting ...

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Publication status:
Published

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Publisher copy:
10.1007/s00125-007-0670-8

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Richards, SK More by this author
Benest, AV More by this author
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Journal:
Diabetologia
Volume:
50
Issue:
7
Pages:
1423-1432
Publication date:
2007-07-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:d0d50cb6-e4e1-4bcd-a4f6-01420cc3d877
Source identifiers:
96049
Local pid:
pubs:96049

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