Journal article
Identification of a gene (lpt-3) required for the addition of phosphoethanolamine to the lipopolysaccharide inner core of Neisseria meningitidis and its role in mediating susceptibility to bactericidal killing and opsonophagocytosis.
- Abstract:
-
We have identified a gene, lpt-3, that is required for the addition of phosphoethanolamine to the 3-position (PEtn-3) on the beta-chain heptose (HepII) of the inner core lipopolysaccharide (LPS) of Neisseria meningitidis (Nm). The presence of this PEtn-3 substituent is characteristic of the LPS of a majority ( approximately 70%) of hypervirulent Nm strains, irrespective of capsular serogroup, and is required for the binding of a previously described monoclonal antibody (mAb B5) to a surface-a...
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- Publication status:
- Published
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- Publisher copy:
- 10.1046/j.1365-2958.2002.02754.x
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Authors
Bibliographic Details
- Journal:
- Molecular microbiology
- Volume:
- 43
- Issue:
- 4
- Pages:
- 931-943
- Publication date:
- 2002-02-01
- DOI:
- EISSN:
-
1365-2958
- ISSN:
-
0950-382X
- Source identifiers:
-
115620
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:115620
- UUID:
-
uuid:d0d4e690-5771-402a-93f2-740a09a5fdf9
- Local pid:
- pubs:115620
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2002
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