Identification of a gene (lpt-3) required for the addition of phosphoethanolamine to the lipopolysaccharide inner core of Neisseria meningitidis and its role in mediating susceptibility to bactericidal killing and opsonophagocytosis.

Mackinnon, FG; Cox, AD; Plested, JS; Tang, CM; Makepeace, K; Coull, PA; Wright, JC; Chalmers, R; Hood, DW; Richards, JC; Moxon, ER

Abstract:

We have identified a gene, lpt-3, that is required for the addition of phosphoethanolamine to the 3-position (PEtn-3) on the beta-chain heptose (HepII) of the inner core lipopolysaccharide (LPS) of Neisseria meningitidis (Nm). The presence of this PEtn-3 substituent is characteristic of the LPS of a majority ( approximately 70%) of hypervirulent Nm strains, irrespective of capsular serogroup, and is required for the binding of a previously described monoclonal antibody (mAb B5) to a surface-a...

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APA Style

Mackinnon, F. G., Cox, A. D., Plested, J. S., Tang, C. M., Makepeace, K., Coull, P. A., Wright, J. C., Chalmers, R., Hood, D. W., Richards, J. C., & Moxon, E. R. (2002). Identification of a gene (lpt-3) required for the addition of phosphoethanolamine to the lipopolysaccharide inner core of Neisseria meningitidis and its role in mediating susceptibility to bactericidal killing and opsonophagocytosis. Molecular Microbiology, 43(4), 931–943.

MLA Style

Mackinnon, F. G., et al. “Identification of a Gene (Lpt-3) Required for the Addition of Phosphoethanolamine to the Lipopolysaccharide Inner Core of Neisseria Meningitidis and Its Role in Mediating Susceptibility to Bactericidal Killing and Opsonophagocytosis.” Molecular Microbiology, vol. 43, no. 4, Molecular microbiology, 2002, pp. 931–43.

Chicago Style

Mackinnon, FG, AD Cox, JS Plested, CM Tang, K Makepeace, PA Coull, JC Wright, et al. 2002. “Identification of a Gene (Lpt-3) Required for the Addition of Phosphoethanolamine to the Lipopolysaccharide Inner Core of Neisseria Meningitidis and Its Role in Mediating Susceptibility to Bactericidal Killing and Opsonophagocytosis.” Molecular Microbiology 43 (4): 931–43.
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