Journal article
Mona/Gads SH3C binding to hematopoietic progenitor kinase 1 (HPK1) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix.
- Abstract:
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Hematopoietic progenitor kinase 1 (HPK1) is implicated in signaling downstream of the T cell receptor. Its non-catalytic, C-terminal half contains several prolinerich motifs, which have been shown to interact with different SH3 domain-containing adaptor proteins in vitro. One of these, Mona/Gads, was also shown to bind HPK1 in mouse T cells in vivo. The region of HPK1 that binds to the Mona/Gads C-terminal SH3 domain has been mapped and shows only very limited similarity to a recently identif...
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- Publication status:
- Published
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- Publisher copy:
- 10.1074/jbc.m402745200
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Bibliographic Details
- Journal:
- Journal of biological chemistry
- Volume:
- 279
- Issue:
- 27
- Pages:
- 28724-28732
- Publication date:
- 2004-07-01
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Source identifiers:
-
7411
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:7411
- UUID:
-
uuid:d0d41983-8577-46d1-b9a0-8e61b7aa31a7
- Local pid:
- pubs:7411
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2004
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