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Bacterial complement escape.

Abstract:
Complement activation is a crucial step in our innate immune defense against invading bacteria. Complement proteins can quickly recognize invading bacteria and subsequently label them for phagocytosis or kill them by direct lysis. In order to survive in the human host, bacterial pathogens have evolved a number of excreted and membrane-bound proteins that interfere with several steps of the complement cascade. In this chapter we summarize the most successful complement-modulating strategies by human bacterial pathogens.

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Publisher copy:
10.1007/978-1-4419-1601-3_3

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Advances in experimental medicine and biology
Volume:
666
Pages:
32-48
Publication date:
2009-01-01
DOI:
ISSN:
0065-2598
URN:
uuid:d0d087fb-3c06-4cc3-97fb-c1bb65ac9998
Source identifiers:
252374
Local pid:
pubs:252374

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