A comparison of bayesian methods for haplotype reconstruction from population genotype data.

Journal article

In this report, we compare and contrast three previously published Bayesian methods for inferring haplotypes from genotype data in a population sample. We review the methods, emphasizing the differences between them in terms of both the models ("priors") they use and the computational strategies they employ. We introduce a new algorithm that combines the modeling strategy of one method with the computational strategies of another. In comparisons using real and simulated data, this new algorit...

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Authors: Stephens, M; Donnelly, P

• Publication status: Published
• Journal: American journal of human genetics
• Volume: 73
• Issue: 5
• Pages: 1162-1169
• Publication date: 2003-11-01
• DOI: 10.1086/379378
• EISSN: 1537-6605
• ISSN: 0002-9297
• Language: English
• Keywords: Research Design; Algorithms; Internet; Humans; Genetics, Population; Software; Bayes Theorem; Models, Genetic; Haplotypes