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Thesis

The role of catechol-O-methyltransferase (COMT) in hippocampal function

Abstract:

Catechol-O-methyltransferase (COMT) metabolises catechol-containing compounds, including dopamine. The aim of this thesis was to investigate whether COMT is involved in hippocampal function. This thesis also explored the role of functional polymorphisms within the COMT gene in the pathogenesis of schizophrenia and schizophrenia-related phenotypes.

First, as part of a study investigating the role of COMT in schizophrenia, human hippocampal COMT mRNA levels were shown to be neither alt...

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Institution:
University of Oxford
Research group:
Molecular Neuropathology Group
Oxford college:
St Peter's College
Department:
Medical Sciences Division - Psychiatry

Contributors

Role:
Supervisor
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Funding agency for:
Linda Maria Laatikainen
Publication date:
2010
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:d0c9e1fa-a052-4af7-aaff-00548365e024
Local pid:
ora:5442

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