Journal article
HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron.
- Abstract:
-
Mutations in the von Hippel-Lindau (VHL) gene are associated with hereditary and sporadic clear cell renal carcinoma. VHL acts in a ubiquitin ligase complex regulating hypoxia-inducible factor-1 (HIF-1), but the link between this function and cancer development is unclear. Here we show that in the kidneys of patients with VHL disease, HIF activation is an early event occurring in morphologically normal single cells within the renal tubules. In comparison, dysplastic lesions, cystic lesions, a...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/s1535-6108(02)00071-5
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Bibliographic Details
- Journal:
- Cancer cell
- Volume:
- 1
- Issue:
- 5
- Pages:
- 459-468
- Publication date:
- 2002-06-01
- DOI:
- EISSN:
-
1878-3686
- ISSN:
-
1535-6108
- Source identifiers:
-
28256
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:28256
- UUID:
-
uuid:d0c9ab35-9640-4829-8843-4f3c2af66464
- Local pid:
- pubs:28256
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2002
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