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Journal article

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron.

Abstract:

Mutations in the von Hippel-Lindau (VHL) gene are associated with hereditary and sporadic clear cell renal carcinoma. VHL acts in a ubiquitin ligase complex regulating hypoxia-inducible factor-1 (HIF-1), but the link between this function and cancer development is unclear. Here we show that in the kidneys of patients with VHL disease, HIF activation is an early event occurring in morphologically normal single cells within the renal tubules. In comparison, dysplastic lesions, cystic lesions, a...

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Publication status:
Published

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Journal:
Cancer cell
Volume:
1
Issue:
5
Pages:
459-468
Publication date:
2002-06-05
DOI:
EISSN:
1878-3686
ISSN:
1535-6108
URN:
uuid:d0c9ab35-9640-4829-8843-4f3c2af66464
Source identifiers:
28256
Local pid:
pubs:28256

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