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Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers

Abstract:

Cyclic adenosine 5′-diphosphate ribose (cADPR) is an emerging Ca2+ -mobilising second messenger. cADPR analogues have been generated as chemical biology tools via both chemo-enzymatic and total synthetic routes. Both routes rely on the cyclisation of a linear precursor to close an 18-membered macrocyclic ring. We show here that, after cyclisation, there are two possible macrocyclic product conformers that may be formed, depending on whether cyclisation occurs to the “right” or the “left” of t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41598-018-33484-x

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
ORCID:
0000-0003-3255-9135
More from this funder
Funding agency for:
Potter, BVL
Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Pages:
Article: 15268
Publication date:
2018-10-15
Acceptance date:
2018-09-27
DOI:
EISSN:
2045-2322
Pubs id:
pubs:922096
URN:
uri:d0c8ccb4-b06f-453a-955b-8f3c220a0160
UUID:
uuid:d0c8ccb4-b06f-453a-955b-8f3c220a0160
Local pid:
pubs:922096

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