- Abstract:
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Cyclic adenosine 5′-diphosphate ribose (cADPR) is an emerging Ca2+ -mobilising second messenger. cADPR analogues have been generated as chemical biology tools via both chemo-enzymatic and total synthetic routes. Both routes rely on the cyclisation of a linear precursor to close an 18-membered macrocyclic ring. We show here that, after cyclisation, there are two possible macrocyclic product conformers that may be formed, depending on whether cyclisation occurs to the “right” or the “left” of t...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
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(pdf, 1.8MB)
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- Publisher copy:
- 10.1038/s41598-018-33484-x
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- Publisher:
- Springer Nature Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 8
- Pages:
- Article: 15268
- Publication date:
- 2018-10-15
- Acceptance date:
- 2018-09-27
- DOI:
- EISSN:
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2045-2322
- Pubs id:
-
pubs:922096
- URN:
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uri:d0c8ccb4-b06f-453a-955b-8f3c220a0160
- UUID:
-
uuid:d0c8ccb4-b06f-453a-955b-8f3c220a0160
- Local pid:
- pubs:922096
- Copyright holder:
- Watt et al.
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 InternationalLicense, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Journal article
Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers
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