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Lessons from the study of T-cell differentiation in persistent human virus infection.

Abstract:

Confusion surrounds the current classification of memory and effector T-cell subsets and there is a lack of consistency in the use of these terms between human and murine studies. The development of peptide-HLA tetrameric complexes ("tetramers") that accurately identify virus-specific T cells and can be used with a range of cell surface and intra-cellular markers has provided further insights in our understanding of the process of T-cell differentiation, or post-thymic development. We propose...

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Publication status:
Published

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Publisher copy:
10.1016/j.smim.2004.02.007

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Journal:
Seminars in immunology
Volume:
16
Issue:
3
Pages:
205-212
Publication date:
2004-06-05
DOI:
EISSN:
1096-3618
ISSN:
1044-5323
URN:
uuid:d0c80000-a755-4c49-a357-70906fb26d9d
Source identifiers:
16037
Local pid:
pubs:16037

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