- Abstract:
-
Bloom syndrome is an autosomal recessive disorder caused by mutations in the RecQ family helicase BLM that is associated with growth retardation and predisposition to cancer. BLM helicase has a high specificity for non-canonical G-quadruplex (G4) DNA structures, which are formed by G-rich DNA strands and play an important role in the maintenance of genomic integrity. Here we used single-molecule FRET to define the mechanism of interaction of BLM helicase with intra-stranded G4 structures. We ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/ncomms6556
-
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- Publisher:
- Nature Publishing Group
- Journal:
- Nature communications
- Volume:
- 5
- Pages:
- 5556
- Publication date:
- 2014
- DOI:
- EISSN:
-
2041-1723
- ISSN:
-
2041-1723
- URN:
-
uuid:d0c5eb26-1df4-4104-8959-445dc51c6229
- Source identifiers:
-
491750
- Local pid:
- pubs:491750
- Language:
- English
- Copyright date:
- 2014
Journal article
Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures.
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