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Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures.

Abstract:

Bloom syndrome is an autosomal recessive disorder caused by mutations in the RecQ family helicase BLM that is associated with growth retardation and predisposition to cancer. BLM helicase has a high specificity for non-canonical G-quadruplex (G4) DNA structures, which are formed by G-rich DNA strands and play an important role in the maintenance of genomic integrity. Here we used single-molecule FRET to define the mechanism of interaction of BLM helicase with intra-stranded G4 structures. We ...

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Publication status:
Published

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Publisher copy:
10.1038/ncomms6556

Authors


Chatterjee, S More by this author
Zagelbaum, J More by this author
Savitsky, P More by this author
Sturzenegger, A More by this author
Huttner, D More by this author
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Publisher:
Nature Publishing Group
Journal:
Nature communications
Volume:
5
Pages:
5556
Publication date:
2014
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
URN:
uuid:d0c5eb26-1df4-4104-8959-445dc51c6229
Source identifiers:
491750
Local pid:
pubs:491750
Language:
English

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