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Journal article

A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.

Abstract:

Autism spectrum disorder (ASD) is a highly heritable disorder of complex and heterogeneous aetiology. It is primarily characterized by altered cognitive ability including impaired language and communication skills and fundamental deficits in social reciprocity. Despite some notable successes in neuropsychiatric genetics, overall, the high heritability of ASD (~90%) remains poorly explained by common genetic risk variants. However, recent studies suggest that rare genomic variation, in particu...

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Publisher copy:
10.1007/s00439-011-1094-6

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Journal:
Human genetics
Volume:
131
Issue:
4
Pages:
565-579
Publication date:
2012-04-05
DOI:
EISSN:
1432-1203
ISSN:
0340-6717
URN:
uuid:d0c5d9bf-c202-48d8-b489-8e314d3d0dcc
Source identifiers:
193238
Local pid:
pubs:193238

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