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Mechanisms of the glycaemic effects of sulfonylureas.

Abstract:

Sulfonylureas are widely used to treat non-insulin dependent diabetes mellitus. These drugs exert their hypoglycaemic effects by stimulating insulin secretion from the pancreatic beta-cell. Their primary mechanism of action is to close ATP-sensitive K-channels in the beta-cell plasma membrane, and so initiate a chain of events which results in insulin release. Recent studies have shown that the beta-cell ATP-sensitive K-channel is a complex of two proteins: a pore-forming subunit (Kir6.2) and...

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Publication status:
Published

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Publisher copy:
10.1055/s-2007-979837

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
Volume:
28
Issue:
9
Pages:
456-463
Publication date:
1996-09-05
DOI:
EISSN:
1439-4286
ISSN:
0018-5043
URN:
uuid:d0c15826-8859-4e72-a6e8-42590ce21c7b
Source identifiers:
113546
Local pid:
pubs:113546

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