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Journal article

Environment specific substitution tables improve membrane protein alignment.

Abstract:

MOTIVATION: Membrane proteins are both abundant and important in cells, but the small number of solved structures restricts our understanding of them. Here we consider whether membrane proteins undergo different substitutions from their soluble counterparts and whether these can be used to improve membrane protein alignments, and therefore improve prediction of their structure. RESULTS: We construct substitution tables for different environments within membrane proteins. As data is scarce, w...

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Publication status:
Published

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Journal:
Bioinformatics (Oxford, England) More from this journal
Volume:
27
Issue:
13
Pages:
i15-i23
Publication date:
2011-07-01
DOI:
EISSN:
1367-4811
ISSN:
1367-4803
Language:
English
Keywords:
Pubs id:
pubs:163910
UUID:
uuid:d0bf29d9-ed1b-43ee-ad57-3ff56ee9d320
Local pid:
pubs:163910
Source identifiers:
163910
Deposit date:
2012-12-19

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