Due to rapid viral and drug resistance mutations, there is a great need for broad-spectrum antiviral therapies that target the host rather than viral processes. This research builds upon previous studies developing α-glucosidase inhibitors known as iminosugars as broad-spectrum antiviral drugs. Initially pH-sensitive liposomes were designed and developed as drug delivery vehicles to enhance cellular internalization for α-glucosidase inhibitors for HIV-1 antiviral treatment. Recent studies ...