Journal article icon

Journal article

A role for midbrain raphe gamma aminobutyric acid neurons in 5-hydroxytryptamine feedback control.

Abstract:

New data show that 5-hydroxytryptamine (5-HT) neurons of the dorsal raphe nucleus (DRN) are subject to feedback control from 5-HT2 receptors, but the circuitry involved is uncertain. This study investigated whether 5-HT2 receptor agonism activates DRN gamma-aminobutyric acid (GABA) neurons, which are known to inhibit neighbouring 5-HT neurons. Systemic administration of the 5-HT2 receptor agonist, DOI, caused a striking increase in Fos-immunoreactivity in the DRN. This effect was abolished by...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
Neuroreport
Volume:
16
Issue:
9
Pages:
891-896
Publication date:
2005-06-05
DOI:
EISSN:
1473-558X
ISSN:
0959-4965
URN:
uuid:d0a9f034-6f53-4378-8f2b-2cd0d44fcda8
Source identifiers:
185145
Local pid:
pubs:185145

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP