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Thesis

Studying protein-DNA interactions in vitro and in vivo using single-molecule photoswitching

Abstract:

Protein-DNA interactions govern the fundamental cellular processes of DNA replication, transcription, repair, and chromosome organisation. Despite their importance, the detailed molecular mechanisms of protein-DNA interactions and their organisation in the cell remain elusive. The complexity of molecular biology demands new experimental concepts that resolve the structural and functional diversity of biomolecules.

In this thesis, I describe fluorescence methods that give a direct vi...

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Institution:
University of Oxford
Research group:
Achillefs Kapanidis
Oxford college:
Queen's College, The
Department:
Mathematical,Physical & Life Sciences Division - Physics - Condensed Matter Physics

Contributors

Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:d0a52864-6d26-44a4-8fb7-5d12624a04ba
Local pid:
ora:7225

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