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CD4+ T cell fate decisions are stochastic, precede cell division, depend on GITR co-stimulation, and are associated with uropodium development

Abstract:

During an immune response, naïve CD4+ T cells proliferate and generate a range of effector, memory, and regulatory T cell subsets, but how these processes are coordinated remains unclear. A traditional model suggests that memory cells use mitochondrial respiration and are survivors from a pool of previously proliferating and glycolytic, but short-lived effector cells. A more recent model proposes a binary commitment to either a memory or effector cell lineage during a first, asymmetric cell d...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0003-1206-4880
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More from this funder
Name:
European Research Council
Grant:
339402-PARIS
More from this funder
Name:
European Commission
Grant:
339402
More from this funder
Name:
Medical Research Council
Grant:
G7904009
More from this funder
Name:
Edward Penley Abraham Research Fund
Publisher:
Frontiers Media
Journal:
Frontiers in Immunology More from this journal
Volume:
9
Pages:
1381
Publication date:
2018-06-18
Acceptance date:
2018-06-04
DOI:
EISSN:
1664-3224
Keywords:
Pubs id:
pubs:854790
UUID:
uuid:d095f663-fd76-45c9-9601-ef80edc1fc5f
Local pid:
pubs:854790
Source identifiers:
854790
Deposit date:
2018-06-04

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