- Abstract:
-
The CD8 coreceptor of cytotoxic T lymphocytes binds to a conserved region of major histocompatibility complex class I molecules during recognition of peptide-major histocompatibility complex (MHC) class I antigens on the surface of target cells. This event is central to the activation of cytotoxic T lymphocyte (CTL) effector functions. The contribution of the MHC complex class I light chain, beta(2)-microglobulin, to CD8alphaalpha binding is relatively small and is mediated mainly through the...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.m201819200
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 277
- Issue:
- 23
- Pages:
- 20840-20846
- Publication date:
- 2002-06-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:d091d5e3-3a61-49c4-99a9-ba4e23b7e80b
- Source identifiers:
-
32078
- Local pid:
- pubs:32078
- Copyright date:
- 2002
Journal article
Novel CD8+ T cell antagonists based on beta 2-microglobulin.
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