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Journal article

Novel CD8+ T cell antagonists based on beta 2-microglobulin.

Abstract:

The CD8 coreceptor of cytotoxic T lymphocytes binds to a conserved region of major histocompatibility complex class I molecules during recognition of peptide-major histocompatibility complex (MHC) class I antigens on the surface of target cells. This event is central to the activation of cytotoxic T lymphocyte (CTL) effector functions. The contribution of the MHC complex class I light chain, beta(2)-microglobulin, to CD8alphaalpha binding is relatively small and is mediated mainly through the...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m201819200

Authors


Vuidepot, AL More by this author
Andersen, TB More by this author
Hutchinson, SL More by this author
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Journal:
The Journal of biological chemistry
Volume:
277
Issue:
23
Pages:
20840-20846
Publication date:
2002-06-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:d091d5e3-3a61-49c4-99a9-ba4e23b7e80b
Source identifiers:
32078
Local pid:
pubs:32078

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