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Nigral degeneration and striatal dopaminergic dysfunction in idiopathic and Parkin-linked Parkinson's disease.

Abstract:

We have used MR segmented inversion recovery ratio imaging (SIRRIM) of the substantia nigra pars compacta to detect and correlate nigral signal change in idiopathic Parkinson's disease (PD) and parkin patients with striatal (18)F-dopa uptake. Nine PD patients, nine parkin patients, and eight control subjects were studied with a combination of MR inversion recovery sequences sensitive to nigral cell loss. Blinded independent observer rating and quantified nigral signal analysis were performed ...

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Publication status:
Published

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Publisher copy:
10.1002/mds.20702

Authors


Scherfler, C More by this author
Hajnal, JV More by this author
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Journal:
Movement disorders : official journal of the Movement Disorder Society
Volume:
21
Issue:
3
Pages:
299-305
Publication date:
2006-03-05
DOI:
EISSN:
1531-8257
ISSN:
0885-3185
URN:
uuid:d08ee6aa-9d63-4d20-bdda-73320cb93958
Source identifiers:
308525
Local pid:
pubs:308525

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