Journal article icon

Journal article

A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.

Abstract:

Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breast and prostate cancer. We performed a genome-wide association study (GWAS) meta-analysis of 21,791 individuals from 10 epidemiologic studies and validated these findings in 7,046 individuals in an ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pgen.1002805

Authors


Coviello, AD More by this author
Wellons, M More by this author
Lehtimäki, T More by this author
Expand authors...
Framingham Heart Study of the National Heart, Lung, and Blood Institute of the National Institutes of Health More from this funder
Boston University School of Medicine More from this funder
SHARe project More from this funder
Expand funders...
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS genetics Journal website
Volume:
8
Issue:
7
Pages:
e1002805
Publication date:
2012-07-05
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:d08d6e26-45d2-40b7-b7bd-95af0bc4dbc1
Source identifiers:
344337
Local pid:
pubs:344337

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP