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A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.

Abstract:

Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breast and prostate cancer. We performed a genome-wide association study (GWAS) meta-analysis of 21,791 individuals from 10 epidemiologic studies and validated these findings in 7,046 individuals in an ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1002805

Authors


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Name:
National Cancer Institute
Grant:
U01-CA98233
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Name:
National Human Genome Research Institute
Grant:
U01-HG-004424
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Name:
U.S. Department of Health and Human Services
Grant:
44221
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Name:
NHGRI
Grant:
U01 HG005152
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Name:
Kuopio, Tampere and Turku University Hospital Medical Funds
Grant:
9N035
Publisher:
Public Library of Science
Journal:
PLoS genetics More from this journal
Volume:
8
Issue:
7
Article number:
e1002805
Publication date:
2012-07-01
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Language:
English
Keywords:
Pubs id:
pubs:344337
UUID:
uuid:d08d6e26-45d2-40b7-b7bd-95af0bc4dbc1
Local pid:
pubs:344337
Source identifiers:
344337
Deposit date:
2012-12-19

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