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Functional connectivity of the pedunculopontine nucleus and surrounding region in parkinson’s disease

Abstract:

Deep brain stimulation of the pedunculopontine nucleus and surrounding region (PPNR) is a novel treatment strategy for gait freezing in Parkinson’s Disease (PD). However, clinical results have been variable, in part because of the paucity of functional information that might help guide selection of the optimal surgical target. In this study, we use simultaneous magnetoencephalography and local field recordings from the PPNR in seven PD patients, to characterise functional connectivity with di...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/cercor/bhw340

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
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Name:
Parkinson’s UK
Funding agency for:
Brown, P
Grant:
F-0903
F-0903
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Name:
National Institute for Health Research
Funding agency for:
Brown, P
Grant:
F-0903
More from this funder
Name:
Rosetrees Trust
Funding agency for:
Brown, P
Grant:
F-0903
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Name:
Medical Research Council
Funding agency for:
Brown, P
Grant:
F-0903
More from this funder
Name:
MRC/EPSRC UK MEG Partnership
Grant:
MR/K005464/1
Publisher:
Oxford University Press
Journal:
Cerebral Cortex More from this journal
Volume:
27
Issue:
1
Pages:
54-67
Publication date:
2016-11-01
Acceptance date:
2016-10-14
DOI:
ISSN:
1460-2199
Keywords:
Pubs id:
pubs:652842
UUID:
uuid:d0875789-47c6-4329-afc7-18ed1784fabb
Local pid:
pubs:652842
Source identifiers:
652842
Deposit date:
2016-10-18

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