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Integrative omics reveals subtle molecular perturbations following ischemic conditioning in a porcine kidney transplant model

Abstract:
Background Remote Ischemic Conditioning (RIC) has been proposed as a therapeutic intervention to circumvent the ischemia/reperfusion injury (IRI) that is inherent to organ transplantation. Using a porcine kidney transplant model, we aimed to decipher the subclinical molecular effects of a RIC regime, compared to non-RIC controls.
Methods Kidney pairs (n = 8 + 8) were extracted from brain dead donor pigs and transplanted in juvenile recipient pigs followi... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12014-022-09343-3

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Role:
Author
ORCID:
0000-0003-4924-7795
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Name:
Medical Research Council
Grant:
MR/R014132/1
Publisher:
BioMed Central
Journal:
Clinical Proteomics More from this journal
Volume:
19
Issue:
1
Article number:
6
Publication date:
2022-02-14
Acceptance date:
2022-02-03
DOI:
EISSN:
1559-0275
ISSN:
1542-6416
Language:
English
Keywords:
Pubs id:
1239720
Local pid:
pubs:1239720
Deposit date:
2022-02-14

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