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Plasmodium falciparum antigenic variation: relationships between in vivo selection, acquired antibody response, and disease severity.

Abstract:

BACKGROUND: Variant surface antigens (VSA) on Plasmodium falciparum-infected erythrocytes are potentially important targets of immunity to malaria. We previously identified a VSA phenotype--VSA with a high frequency of antibody recognition (VSA(FoRH))--that is associated with young host age and severe malaria. We hypothesized that VSA(FoRH) are positively selected by host molecules such as intercellular adhesion molecule 1 (ICAM1) and CD36 and dominate in the absence of an effective immune r...

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Publication status:
Published

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Publisher copy:
10.1086/432761

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
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Journal:
The Journal of infectious diseases
Volume:
192
Issue:
6
Pages:
1119-1126
Publication date:
2005-09-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:d07e95e5-dc59-4296-98fa-ca14ce592231
Source identifiers:
23328
Local pid:
pubs:23328

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