- Abstract:
-
BACKGROUND: Variant surface antigens (VSA) on Plasmodium falciparum-infected erythrocytes are potentially important targets of immunity to malaria. We previously identified a VSA phenotype--VSA with a high frequency of antibody recognition (VSA(FoRH))--that is associated with young host age and severe malaria. We hypothesized that VSA(FoRH) are positively selected by host molecules such as intercellular adhesion molecule 1 (ICAM1) and CD36 and dominate in the absence of an effective immune r...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1086/432761
-
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- Journal:
- The Journal of infectious diseases
- Volume:
- 192
- Issue:
- 6
- Pages:
- 1119-1126
- Publication date:
- 2005-09-05
- DOI:
- EISSN:
-
1537-6613
- ISSN:
-
0022-1899
- URN:
-
uuid:d07e95e5-dc59-4296-98fa-ca14ce592231
- Source identifiers:
-
23328
- Local pid:
- pubs:23328
- Copyright date:
- 2005
Journal article
Plasmodium falciparum antigenic variation: relationships between in vivo selection, acquired antibody response, and disease severity.
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