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Dominant tolerance: activation thresholds for peripheral generation of regulatory T cells.

Abstract:

In recent years, regulatory T (Treg) cells have reached centre-stage in immune tolerance research. A role for Treg cells in preventing autoimmunity or generating transplantation tolerance is now undisputed. However, in spite of a surge in publications dedicated to Treg cells, surprisingly little is known about their induction, biology and mechanisms of action. In this Opinion, we discuss the facts and the controversies regarding their role in transplantation tolerance. We suggest that periphe...

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Publication status:
Published

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Publisher copy:
10.1016/j.it.2004.12.007

Authors


Le Moine, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
Trends in immunology
Volume:
26
Issue:
3
Pages:
130-135
Publication date:
2005-03-05
DOI:
EISSN:
1471-4981
ISSN:
1471-4906
URN:
uuid:d07c05ed-97b4-47a6-a7d3-76b84d5bebad
Source identifiers:
23741
Local pid:
pubs:23741

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