Journal article
PHOrming the inflammasome: phosphorylation is a critical switch in inflammasome signalling
- Abstract:
-
Inflammasomes are protein complexes in the innate immune system that regulate the production of pro-inflammatory cytokines and inflammatory cell death. Inflammasome activation and subsequent cell death often occur within minutes to an hour, so the pathway must be dynamically controlled to prevent excessive inflammation and the development of inflammatory diseases. Phosphorylation is a fundamental post-translational modification that allows rapid control over protein function and the phosphory...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Biochemical Society Publisher's website
- Journal:
- Biochemical Society Transactions Journal website
- Volume:
- 49
- Issue:
- 6
- Pages:
- 2495-2507
- Publication date:
- 2021-12-02
- Acceptance date:
- 2021-10-11
- DOI:
- EISSN:
-
1470-8752
- ISSN:
-
0300-5127
- Pmid:
-
34854899
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1222783
- Local pid:
- pubs:1222783
- Deposit date:
- 2021-12-17
Terms of use
- Copyright holder:
- McKee et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND). Open access for this article was enabled by the participation of Queen's University Belfast in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC.
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