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Journal article

PHOrming the inflammasome: phosphorylation is a critical switch in inflammasome signalling

Abstract:

Inflammasomes are protein complexes in the innate immune system that regulate the production of pro-inflammatory cytokines and inflammatory cell death. Inflammasome activation and subsequent cell death often occur within minutes to an hour, so the pathway must be dynamically controlled to prevent excessive inflammation and the development of inflammatory diseases. Phosphorylation is a fundamental post-translational modification that allows rapid control over protein function and the phosphory...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1042/bst20200987

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
ORCID:
0000-0003-1441-1727
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Role:
Author
ORCID:
0000-0002-7359-6023
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Name:
Medical Research Council
Grant:
MR/S000623/1
Publisher:
Biochemical Society
Journal:
Biochemical Society Transactions More from this journal
Volume:
49
Issue:
6
Pages:
2495-2507
Publication date:
2021-12-02
Acceptance date:
2021-10-11
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
Pmid:
34854899
Language:
English
Keywords:
Pubs id:
1222783
Local pid:
pubs:1222783
Deposit date:
2021-12-17

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