IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes.

Journal article

OBJECTIVE: Interleukin-6 (IL-6) is a pro-inflammatory cytokine which is a prognostic marker associated with left ventricular contractile dysfunction and heart failure. On the other hand, IL-6 activates signalling pathways which mediate delayed ischemic preconditioning. We have therefore studied the cellular mechanisms of IL-6-induced cardioprotection. METHODS: Inducible nitric oxide synthase (iNOS) expression, cardiomyocyte calcium handling, mitochondrial energetics, and the activation of pr...

Expand abstract

Authors: Smart, N; Mojet, M; Latchman, D; Marber, MS; Duchen, MR

• Journal: Cardiovascular research
• Volume: 69
• Issue: 1
• Pages: 164-177
• Publication date: 2006-01-01
• DOI: 10.1016/j.cardiores.2005.08.017
• EISSN: 1755-3245
• ISSN: 0008-6363
• Language: English
• Keywords: Microscopy, Confocal; Myocytes, Cardiac; Calcium; Cytosol; Nitric Oxide Synthase Type II; Myocardial Reperfusion Injury; Enzyme Inhibitors; Nitric Oxide; Androstadienes; Animals; Rats, Sprague-Dawley; Interleukin-6; Phosphatidylinositol 3-Kinases; Mitochondria, Heart; Rats; Membrane Potentials; Cells, Cultured; Sarcoplasmic Reticulum