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Different effects of isolation-rearing and neonatal MK-801 treatment on attentional modulations of prepulse inhibition of startle in rats

Abstract:

Rational Prepulse inhibition (PPI) is suppression of the startle reflex by a weaker sensory stimulus (prepulse) preceding the startling stimulus. In people with schizophrenia, impairment of attentional modulation of PPI, but not impairment of baseline PPI, is correlated with symptom severity. In rats, both fear conditioning of prepulse and perceptually spatial separation between the conditioned prepulse and a noise masker enhance PPI (the paradigms of attentional modulation of PPI).

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00213-016-4351-5

Authors


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Institution:
University of Oxford
Oxford college:
Queens College
Role:
Author
More from this funder
Name:
National Clinical Key Construction Project in Chinese Medicine
Grant:
2100299
More from this funder
Name:
Clinical Characteristics Program of Beijing Municipal Science and Technology Commission
Grant:
Z151100004015061
More from this funder
Name:
National Natural Science Foundation of China
Grant:
31470987
More from this funder
Name:
The “985” Project of Peking University
Publisher:
Springer
Journal:
Psychopharmacology More from this journal
Volume:
233
Issue:
17
Pages:
3089-3102
Publication date:
2016-07-01
Acceptance date:
2016-06-02
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
Keywords:
Pubs id:
pubs:632954
UUID:
uuid:d06e32ef-6490-431a-86c8-fdcec3e9f247
Local pid:
pubs:632954
Source identifiers:
632954
Deposit date:
2016-08-18

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