Journal article
Different effects of isolation-rearing and neonatal MK-801 treatment on attentional modulations of prepulse inhibition of startle in rats
- Abstract:
-
Rational Prepulse inhibition (PPI) is suppression of the startle reflex by a weaker sensory stimulus (prepulse) preceding the startling stimulus. In people with schizophrenia, impairment of attentional modulation of PPI, but not impairment of baseline PPI, is correlated with symptom severity. In rats, both fear conditioning of prepulse and perceptually spatial separation between the conditioned prepulse and a noise masker enhance PPI (the paradigms of attentional modulation of PPI).
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ National Clinical Key Construction Project in Chinese Medicine
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Grant:
2100299
+ Clinical Characteristics Program of Beijing Municipal Science and Technology Commission
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Grant:
Z151100004015061
The “985” Project of Peking University
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Bibliographic Details
- Publisher:
- Springer Publisher's website
- Journal:
- Psychopharmacology Journal website
- Volume:
- 233
- Issue:
- 17
- Pages:
- 3089-3102
- Publication date:
- 2016-07-01
- Acceptance date:
- 2016-06-02
- DOI:
- EISSN:
-
1432-2072
- ISSN:
-
0033-3158
Item Description
- Keywords:
- Pubs id:
-
pubs:632954
- UUID:
-
uuid:d06e32ef-6490-431a-86c8-fdcec3e9f247
- Local pid:
- pubs:632954
- Source identifiers:
-
632954
- Deposit date:
- 2016-08-18
Terms of use
- Copyright holder:
- Springer-Verlag Berlin Heidelberg
- Copyright date:
- 2016
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from Springer at: 10.1007/s00213-016-4351-5
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