Matrix metallopropteinases in heart failure.

Journal article

Heart failure (HF) represents a complex multifactorial syndrome, characterized by crucial structural and functional abnormalities of the myocardium. Matrix metalloproteinases are associated with left ventricular dysfunction, adverse left ventricular remodelling and prognosis after acute myocardial infarction. There is a strong association between oxidative stress and MMPs in the pathophysiology of HF. As MMPs are strongly associated to the pathogenesis and pathophysiology of HF, several agent...

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Authors: Tousoulis, D; Kampoli, A; Papageorgiou, N; Antoniades, C; Siasos, G

• Journal: Current topics in medicinal chemistry
• Volume: 12
• Issue: 10
• Pages: 1181-1191
• Publication date: 2012-01-01
• DOI: 10.2174/1568026611208011181
• EISSN: 1873-4294
• ISSN: 1568-0266
• Language: English
• Keywords: Angiotensin-Converting Enzyme Inhibitors; Animals; Ventricular Dysfunction, Left; Myocardial Infarction; Heart Failure; Ventricular Remodeling; Matrix Metalloproteinases; Humans