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Which GABA(A) receptor subunits are necessary for tonic inhibition in the hippocampus?

Abstract:

GABA(A) receptors (GABA(A)Rs) assembled of different subunits mediate tonic and phasic inhibition in hippocampal neurons. CA1/CA3 pyramidal cells (PCs) predominantly express alpha5 subunits whereas dentate gyrus granule cells (DGGCs) and molecular layer (ML) interneurons predominantly express delta subunits. Both alpha5- and delta-containing GABA(A)Rs mediate tonic inhibition. We have shown previously that mice lacking alpha5 subunits (Gabra5-/-) have a residual tonic current in CA1/CA3 PCs b...

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Publication status:
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
28
Issue:
6
Pages:
1421-1426
Publication date:
2008-02-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:d0688cfd-89c0-4183-890e-4085f9fc5178
Source identifiers:
246734
Local pid:
pubs:246734

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