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Mapping MHC-encoded susceptibility and resistance in primary sclerosing cholangitis: the role of MICA polymorphism.

Abstract:

BACKGROUND and AIMS: Recent studies suggest that major histocompatibility complex-encoded susceptibility to primary sclerosing cholangitis (PSC) maps to the HLA B-TNFA region on chromosome 6p21.3. METHODS: The present study uses a standard polymerase chain reaction protocol to investigate the 16 common alleles of the MICA locus as candidates in 2 patient populations (King's College Hospital, London, and John Radcliffe Hospital, Oxford). RESULTS: The MICA*002 allele was found in 4 of 62 (6.4%)...

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Publication status:
Published

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Publisher copy:
10.1053/gast.2001.24041

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Journal:
Gastroenterology More from this journal
Volume:
120
Issue:
6
Pages:
1475-1482
Publication date:
2001-05-01
DOI:
EISSN:
1528-0012
ISSN:
0016-5085
Language:
English
Keywords:
Pubs id:
pubs:92420
UUID:
uuid:d067e6e7-018e-4f46-9d73-fcdfb316423f
Local pid:
pubs:92420
Source identifiers:
92420
Deposit date:
2012-12-19

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